Age Reversal in Singapore: Activating Longevity Genes with Cutting-Edge Science
- Derrick Seeto
- Apr 24
- 1 min read
Updated: Aug 13
Dr. David Sinclair's Anti-Aging Protocol
Singapore's Aging Crisis
With 25% of the population projected to be over 65 by 2030 (MSF 2023), biological age reduction has become a national priority. Our clinic adapts Dr. Sinclair's Harvard research for tropical urban living.
The Epigenetic Breakthrough
Sinclair's work shows we can influence:
- Sirtuin activation (NAD+-dependent longevity proteins)
- mTOR regulation (cellular recycling pathway)
- AMPK stimulation (energy sensing enzyme)

The 3-Pillar Protocol
1. Hyperbaric Oxygen Therapy (HBOT)
- 90-minute sessions at 1.5 ATA
- Increases stem cell production by 800% (Aging 2020)
- Our Orchard clinic features Singapore's first multi-person HBOT chamber
2. Time-Restricted Nutrition
- 16-hour fasting window (8PM-12PM)
- Key supplements:
- NMN (500mg/day) - increases NAD+ by 40%
- Trans-resveratrol (1g with fats) - activates SIRT1
- Spermidine (10mg) - enhances autophagy
3. Metabolic Stress Cycling
- Weekly high-intensity training (VO2 max intervals)
- Monthly 36-hour fasts with electrolyte support
- Sauna/cold plunge contrast therapy
Local Adaptations
- Modified fasting protocols for hawker center diets
- Heat-acclimated workout regimens
- Pollution-defense nutraceuticals (broccoli sprout extract)
Client Results at 6 Months
- Average 5.2 year reduction in epigenetic age
- 28% improvement in mitochondrial function
- 17% increase in telomere length (qPCR tested)
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